Not known Factual Statements About pkrrating
The interfacial residues are very conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a design where by activating RNA serves to be a scaffold to bind various PKR monomers, increasing th